The Drosophila Cadherin Fat Regulates Tissue Size and Planar Cell Polarity through Different Domains

@inproceedings{Zhao2013TheDC,
  title={The Drosophila Cadherin Fat Regulates Tissue Size and Planar Cell Polarity through Different Domains},
  author={Xuesong Zhao and Chung-Hui Yang and Michael A. Simon},
  booktitle={PloS one},
  year={2013}
}
The Drosophila Cadherin Fat (Ft) has been identified as a crucial regulator of tissue size and Planar Cell Polarity (PCP). However, the precise mechanism by which Ft regulates these processes remains unclear. In order to advance our understanding of the action of Ft, we have sought to identify the crucial Ft effector domains. Here we report that a small region of the Ft cytoplasmic domain (H2 region) is both necessary and sufficient, when membrane localized, to support viability and prevent… CONTINUE READING
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