The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation.

@article{Baba1999TheDB,
  title={The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation.},
  author={Kotaro Baba and Ayumi Takeshita and Kei Majima and Ryu Ueda and Shinji Kondo and Naoto Juni and Daisuke Yamamoto},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 6},
  pages={4405-13}
}
We isolated a Drosophila fickleP (ficP) mutant with a shortened copulatory duration and reduced adult-stage life span. The reduced copulatory duration is ascribable to incomplete fusion of the left and right halves of the apodeme that holds the penis during copulation. ficP is an intronic mutation occurring in the Btk gene, a gene which encodes two forms (type 1 and type 2) of a Bruton's tyrosine kinase (Btk) family cytoplasmic tyrosine kinase as a result of alternative exon usage. The ficP… CONTINUE READING

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