The Drosophila Broad-Complex early gene directly regulates late gene transcription during the ecdysone-induced puffing cascade.

@article{Crossgrove1996TheDB,
  title={The Drosophila Broad-Complex early gene directly regulates late gene transcription during the ecdysone-induced puffing cascade.},
  author={Kirsten Crossgrove and Cynthia A Bayer and James W. Fristrom and Gregory M. Guild},
  journal={Developmental biology},
  year={1996},
  volume={180 2},
  pages={745-58}
}
The ensemble of tissue-specific changes that drives Drosophila metamorphosis is initiated by the steroid hormone ecdysone and proceeds through a transcriptional cascade comprised of primary response transcriptional regulators and secondary response structural genes. The Broad-Complex (BR-C) primary response early gene is composed of several distinct genetic functions and encodes a family of related transcription factor isoforms. Our objective in this study was to determine whether individual BR… CONTINUE READING

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