The Drosophila BMP Type II Receptor Wishful Thinking Regulates Neuromuscular Synapse Morphology and Function

@article{Marqus2002TheDB,
  title={The Drosophila BMP Type II Receptor Wishful Thinking Regulates Neuromuscular Synapse Morphology and Function},
  author={Guillermo Marqu{\'e}s and Hong Bao and Theodor E. Haerry and Mary Jane Shimell and Peter Duchek and Bing Zhang and Michael B O'connor},
  journal={Neuron},
  year={2002},
  volume={33},
  pages={529-543}
}
Proper synaptic development is critical for establishing all aspects of neural function including learning, memory, and locomotion. Here, we describe the phenotypic consequences of mutations in the wishful thinking (wit) gene, the Drosophila homolog of the vertebrate BMP type II receptor. Mutations in wit result in pharate lethality that can be rescued by expression of a wit transgene in motor neurons but not in muscles. Mutant larvae exhibit small synapses, severe defects in evoked junctional… CONTINUE READING
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