The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition

@article{Sibon1999TheDA,
  title={The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition},
  author={Ody C. M. Sibon and Anne Laurençon and R. Scott Hawley and William E. Theurkauf},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={302-312}
}
BACKGROUND Drosophila embryogenesis is initiated by 13 rapid syncytial mitotic divisions that do not require zygotic gene activity. This maternally directed cleavage phase of development terminates at the midblastula transition (MBT), at which point the cell cycle slows dramatically, membranes surround the cortical nuclei to form a cellular blastoderm, and zygotic gene expression is first required. RESULTS We show that embryos lacking Mei-41, a Drosophila homologue of the ATM tumor suppressor… CONTINUE READING

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