The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1 and Cyclin D1 and induces cell cycle exit and neuronal differentiation

@inproceedings{Soppa2014TheDS,
  title={The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1 and Cyclin D1 and induces cell cycle exit and neuronal differentiation},
  author={Ulf Soppa and Julian Schumacher and Victoria Florencio Ortiz and Tobias Pasqualon and Francisco J Tejedor and Walter Becker},
  booktitle={Cell cycle},
  year={2014}
}
A fundamental question in neurobiology is how the balance between proliferation and differentiation of neuronal precursors is maintained to ensure that the proper number of brain neurons is generated. Substantial evidence implicates DYRK1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A) as a candidate gene responsible for altered neuronal development and brain abnormalities in Down syndrome. Recent findings support the hypothesis that DYRK1A is involved in cell cycle control… CONTINUE READING
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DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome.

Proceedings of the National Academy of Sciences of the United States of America • 2017
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