The Down syndrome critical region regulates retinogeniculate refinement.

  title={The Down syndrome critical region regulates retinogeniculate refinement.},
  author={Martina Blank and Peter G. Fuerst and Beth Stevens and Navid Nouri and Lowry A Kirkby and Deepti R. Warrier and Ben A Barres and Marla B Feller and Andrew D Huberman and Robert W Burgess and Craig C. Garner},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={31 15},
Down syndrome (DS) is a developmental disorder caused by a third chromosome 21 in humans (Trisomy 21), leading to neurological deficits and cognitive impairment. Studies in mouse models of DS suggest that cognitive deficits in the adult are associated with deficits in synaptic learning and memory mechanisms, but it is unclear whether alterations in the early wiring and refinement of neuronal circuits contribute to these deficits. Here, we show that early developmental refinement of visual… CONTINUE READING


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