The Dose-Dependent Organ-Specific Effects of a Dipeptidyl Peptidase-4 Inhibitor on Cardiovascular Complications in a Model of Type 2 Diabetes.

@article{Moon2016TheDO,
  title={The Dose-Dependent Organ-Specific Effects of a Dipeptidyl Peptidase-4 Inhibitor on Cardiovascular Complications in a Model of Type 2 Diabetes.},
  author={Ju-young Moon and Jong Shin Woo and Jung-Woo Seo and Arah Lee and Dong Jin Kim and Y Kim and S Joseph Kim and Kyung Hye Lee and S. Lim and Xian Wu Cheng and Sang-Ho Lee and Weon Kim},
  journal={PloS one},
  year={2016},
  volume={11 3},
  pages={e0150745}
}
OBJECTIVE Although dipeptidyl peptidase-4 (DPP-4) inhibitors have been suggested to have a non-glucoregulatory protective effect in various tissues, the effects of long-term inhibition of DPP-4 on the micro- and macro-vascular complications of type 2 diabetes remain uncertain. The aim of the present study was to investigate the organ-specific protective effects of DPP-4 inhibitor in rodent model of type 2 diabetes. METHODS Eight-week-old diabetic and obese db/db mice and controls (db/m mice… CONTINUE READING
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