The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence.

@article{Mehra2015TheDR,
  title={The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence.},
  author={Smriti Mehra and Taylor W. Foreman and Peter J. Didier and Muhammad H. Ahsan and Teresa A Hudock and Ryan S Kissee and Nadia Abrahams Golden and Uma Shankar Gautam and Ann-Marie F. Johnson and X. Alvarez and Kasi E Russell-Lodrigue and Lara A. Doyle and Chad J Roy and Tianhua Niu and James L. Blanchard and Shabaana A Khader and Andrew A Lackner and David R. Sherman and Deepak Kaushal},
  journal={American journal of respiratory and critical care medicine},
  year={2015},
  volume={191 10},
  pages={1185-96}
}
RATIONALE Hypoxia promotes dormancy by causing physiologic changes to actively replicating Mycobacterium tuberculosis. DosR controls the response of M. tuberculosis to hypoxia. OBJECTIVES To understand DosR's contribution in the persistence of M. tuberculosis, we compared the phenotype of various DosR regulon mutants and a complemented strain to M. tuberculosis in macaques, which faithfully model M. tuberculosis infection. METHODS We measured clinical and microbiologic correlates of… CONTINUE READING
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