The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

  title={The Dorsoventral Regulatory Gene Cassette sp{\"a}tzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults},
  author={Bruno Lemaitre and Emmanuelle Nicolas and Lydia Michaut and J M Reichhart and Jules A. Hoffmann},
The cytokine-induced activation cascade of NF-kappaB in mammals and the activation of the morphogen dorsal in Drosophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB). Here we demonstrate that these parallels extend to the immune response of Drosophila. In particular, the intracellular components of the dorsoventral signaling pathway (except for dorsal) and the extracellular Toll ligand, spätzle, control expression of the… CONTINUE READING
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