The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse.

@article{Levi2003TheDH,
  title={The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse.},
  author={Giovanni Levi and Adam C. Puche and Stefano Mantero and Ottavia Barbieri and Sonya Trombino and Laura Paleari and A. Egeo and Giorgio Roberto Merlo},
  journal={Molecular and cellular neurosciences},
  year={2003},
  volume={22 4},
  pages={530-43}
}
The distalless-related homeogene Dlx5 is expressed in the olfactory placodes and derived tissues and in the anterior-basal forebrain. We investigated the role of Dlx5 in olfactory development. In Dlx5(-/-) mice, the olfactory bulbs (OBs) lack glomeruli, exhibit disorganized cellular layers, and show reduced numbers of TH- and GAD67-positive neurons. The olfactory epithelium in Dlx5(-/-) mice is composed of olfactory receptor neurons (ORNs) that appear identical to wild-type ORNs, but their… CONTINUE READING