The Dkk1 dose is critical for eye development.

  title={The Dkk1 dose is critical for eye development.},
  author={Oliver Lieven and Ulrich U R{\"u}ther},
  journal={Developmental biology},
  volume={355 1},
During mammalian ocular development, several signaling pathways control the spatiotemporal highly defined realization of the three-dimensional eye architecture. Given the complexity of these inductive signals, the developing eye is a sensitive organ for several diseases. In this study, we investigated a Dkk1+/- haploinsufficiency during eye development, resulting in coloboma and anterior eye defects, two common developmental eye disorders. Dkk1 impacts eye development from a defined… CONTINUE READING

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