The Diverse Roles of Mast Cells

  title={The Diverse Roles of Mast Cells},
  author={Michael F. Gurish and K Frank Austen},
  journal={The Journal of Experimental Medicine},
  pages={f1 - f6}
In this issue, Matsumoto et al. (1) report that histamine exocytosed from brain mast cells (MCs) after activation by antigenic cross-linking of the high affinity IgE receptor (Fc ⑀ RI) acts via Hl receptors at the hypothalamus to elicit corticotropin-releasing factor (CRF). These findings reveal a homeostatic response to a pathobiologic event in the dog. Conversely, CRF can also be proinflammatory by mediating activation of tissue MCs (2). This action is implicated in the acute immobilization… CONTINUE READING


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