The Diverse Actions of Volatile and Gaseous Anesthetics on Human-cloned 5-Hydroxytryptamine3 Receptors Expressed in Xenopus Oocytes

@article{Suzuki2002TheDA,
  title={The Diverse Actions of Volatile and Gaseous Anesthetics on Human-cloned 5-Hydroxytryptamine3 Receptors Expressed in Xenopus Oocytes},
  author={Takahiro Suzuki and Hideki Koyama and Masahiro Sugimoto and Ichirō Uchida and Takashi Mashimo},
  journal={Anesthesiology},
  year={2002},
  volume={96},
  pages={699-704}
}
Background General anesthetics can modulate the 5-hydroxytryptamine type 3 (5-HT3) receptor, which may be involved in processes mediating nausea and vomiting, and peripheral nociception. The effects of the new volatile anesthetic sevoflurane and the gaseous anesthetics nitrous oxide (N2O) and xenon (Xe) on the 5-HT3 receptor have not been well-characterized. Methods Homomeric human-cloned 5-HT3A receptors were expressed in Xenopus oocytes. The effects of halothane, isoflurane, sevoflurane, N2O… 

Molecular Properties Important for Inhaled Anesthetic Action on Human 5-HT3A Receptors

Modulation of human 5- HT3A-mediated currents by volatile anesthetics exhibits a dependence on molecular volume consistent with the n-alcohols, suggesting that both classes of agents may enhance 5-HT3A receptor function via the same mechanism.

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Nitrous Oxide and Xenon Inhibit the Human (&agr;7)5 Nicotinic Acetylcholine Receptor Expressed in Xenopus Oocyte

Results suggest that inhibition of the (&agr;7)5 nACh receptor by N2O and Xe may play a role in their anesthetic effects.

N-Methyl-d-Aspartate Receptor Channel Blocker–Like Discriminative Stimulus Effects of Nitrous Oxide Gas

The results support the hypothesis that the discriminative stimulus effects of N2O are at least partially mediated by NMDA antagonist effects similar to those produced by channel blockers, however, as none of the drugs tested fully mimicked the stimulus results of N 2O, other mechanisms may also be involved.

Xenon Acts by Inhibition of Non–N-methyl-d-aspartate Receptor–mediated Glutamatergic Neurotransmission in Caenorhabditis elegans

Xenon acts in Caenorhabditis elegans to alter locomotion through a mechanism requiring the non-NMDA glutamate receptor encoded by glr-1, unlike for the action of nitrous oxide in C. elegans, the NMDA receptors encoded by nmR-1 is not essential for sensitivity to xenon.

Molecular interactions between general anesthetics and the 5HT2B receptor

The molecular interactions between propofol and isoflurane with the 5-HT2B class of receptors were discovered and characterized and implicates the serotonergic GPCRs as potential anesthetic targets.
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