The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis.

@article{Knight2015TheDO,
  title={The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis.},
  author={Gwenan M Knight and Caroline Colijn and Sourya Shrestha and Mariam O Fofana and Frank Cobelens and Richard G. White and David W. Dowdy and Ted Cohen},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2015},
  volume={61Suppl 3},
  pages={S147-54}
}
BACKGROUND Drug resistance poses a serious challenge for the control of tuberculosis in many settings. It is well established that the expected future trend in resistance depends on the reproductive fitness of drug-resistant Mycobacterium tuberculosis. However, the variability in fitness between strains with different resistance-conferring mutations has been largely ignored when making these predictions. METHODS We developed a novel approach for incorporating the variable fitness costs of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…