The Distinct Effects of Lipid Emulsions Used for “Lipid Resuscitation” on Gating and Bupivacaine-Induced Inhibition of the Cardiac Sodium Channel Nav1.5

@article{Nadrowitz2013TheDE,
  title={The Distinct Effects of Lipid Emulsions Used for “Lipid Resuscitation” on Gating and Bupivacaine-Induced Inhibition of the Cardiac Sodium Channel Nav1.5},
  author={Felix Nadrowitz and Carsten Stoetzer and Nilufar Foadi and J{\"o}rg Ahrens and Florian Wegner and Angelika Lampert and Wolfgang Koppert and Jeanne de la Roche and Andreas Leffler},
  journal={Anesthesia \& Analgesia},
  year={2013},
  volume={117},
  pages={1101–1108}
}
BACKGROUND: Systemic administration of lipid emulsions is an established treatment for local anesthetic intoxication. However, it is unclear by which mechanisms lipids achieve this function. The high cardiac toxicity of the lipophilic local anesthetic bupivacaine probably results from a long-lasting inhibition of the cardiac Na+ channel Nav1.5. In this study, we sought to determine whether lipid emulsions functionally interact with Nav1.5 or counteract inhibition by bupivacaine. METHODS: Human… 
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Infusion of lipid emulsion resulted in greater survival in this rabbit model of intravenous clomipramine toxicity and plasma exchange performed in conjunction with administration of Lipid emulsion failed to result in significant extracorporeal clomIPramine elimination.
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