The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members

@inproceedings{Almn2012TheDA,
  title={The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members},
  author={Markus S{\"a}llman Alm{\'e}n and Nathalie Bringeland and Robert Fredriksson and Helgi B. Schi{\"o}th},
  booktitle={PloS one},
  year={2012}
}
The Interferon induced transmembrane proteins (IFITM) are a family of transmembrane proteins that is known to inhibit cell invasion of viruses such as HIV-1 and influenza. We show that the IFITM genes are a subfamily in a larger family of transmembrane (TM) proteins that we call Dispanins, which refers to a common 2TM structure. We mined the Dispanins in 36 eukaryotic species, covering all major eukaryotic groups, and investigated their evolutionary history using Bayesian and maximum likelihood… CONTINUE READING

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