The Discriminative Stimulus Properties of EGb 761, an Extract of Ginkgo biloba

  title={The Discriminative Stimulus Properties of EGb 761, an Extract of Ginkgo biloba
  author={Jerrold C. Winter and Deborah Timineri},
  journal={Pharmacology Biochemistry and Behavior},

Pharmacological and biochemical effects of Ginkgo biloba extract on learning, memory consolidation and motor activity in old rats.

Long-term administration of Ginkgo biloba extract can improve spatial memory and motivation with significant changes in the content and metabolism of monoamines in several brain regions.

Ginkgo biloba extract attenuates hippocampal neuronal loss and cognitive dysfunction resulting from trimethyltin in mice.

Beneficial Effects of Ginkgo biloba in Neurological Disorders

Ginkgo biloba leaves extract produces memory boosting and mental altering effects, which are due to antioxidant- and neurogenesis-promoting properties of flavonols of G. biloba, which possess potent central nervous system (CNS) activity.

Ginkgo biloba Extract: Review of CNS Effects

  • L. PontoS. Schultz
  • Biology, Medicine
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
  • 2003
The purpose of this paper is to review the scientific literature on the central nervous system effects of GBE, with emphasis on the potential mechanisms of action.

Neuroprotective effects of Ginkgo biloba extract

The experimental results on the mechanism of neuroprotection induced by standardized extract of Ginkgo biloba leaves (EGb 761) and its constituents include those on cerebral blood flow, neurotransmitter systems, cellular redox state and nitric oxide level.

Ginkgo biloba for Attention-Deficit/Hyperactivity Disorder in children and adolescents: A double blind, randomized controlled trial

Comparative Study Between The Clinical Effects of Glucosamine/Gingko Biloba & Glucosamine/Chondroitin in Treatment of Knee Osteoarthritis

It was found that all components of KOOS including pain score, symptoms score, activity of daily living (ADL), quality of life (QOL) and sport & recreation scores were significantly elevated in both combinations, however, glucosamine /gingko biloba showed a better improvement when statistically compared with the combination of glucosamines/chondroitin.



Effects of an extract of Ginkgo biloba on learning and memory in mice

  • E. Winter
  • Medicine, Psychology
    Pharmacology Biochemistry and Behavior
  • 1991

Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination.

  • J. C. WinterR. Rabin
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1992
The present data suggest that rats trained with yohimbine as a discriminative stimulus generalize to drugs with minimal affinity for the alpha 2 adrenoceptor but with high affinity for 5-HT1A receptors.

Memory effects of standardized extracts of Panax ginseng (G115), Ginkgo biloba (GK 501) and their combination Gincosan (PHL-00701).

The results suggest that the Panax ginseng G115 and the Ginkgo biloba GK501 extracts possess properties similar in every respect to those of nootropic drugs.

EGb 761 inhibits stress-induced polydipsia in rats