The Discovery of the Causal Agent of the Tobacco Mosaic Disease

  title={The Discovery of the Causal Agent of the Tobacco Mosaic Disease},
  author={Milton Zaitlin},
The discovery of the causal agent of the disease causing mosaic and distortion on tobacco plants, with the concomitant realization that the etiologic agent was something unique - a virus - came at the end of the 19th century. This marked the beginning of the science of virology, although many diseases now known to be caused by viruses were described much earlier. This review documents the contributions of the three men who were the pioneers in this work, namely, Adolph Mayer, Dmitrii Iwanowski… 
Advances in Understanding Plant Viruses and Virus Diseases.
In this period, plant virology has played a significant role in formulating an understanding of the mechanisms of gene silencing and recombination, plasmodesmatal function, systemic acquired resistance, and in developing methods for pathogen detection.
On the historical significance of Beijerinck and his contagium vivum fluidum for modern virology
  • N. Sankaran
  • Biology
    History and philosophy of the life sciences
  • 2018
This paper considers the foundational role of the contagium vivum fluidum—first proposed by the Dutch microbiologist Martinus Beijerinck in 1898—in the history of virology, particularly in shaping
Writing the history of virology in the twentieth century: Discovery, disciplines, and conceptual change.
Tobacco mosaic virus: a model system for plant biology.
The history of TMV illustrates how pragmatic strategies to control an economically important disease of tobacco have had unexpected and transforming effects across platforms that impinge on plant health and public health.
Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies
This review gives the reader a ride through strikingly diverse achievements obtained with TMV-based particles, compares them to the progress with related viruses, and focuses on latest results revealing special advantages for enzyme-based biosensing formats, which might be of high interest for diagnostics employing 'systems-on-a-chip'.
Viruses and Viroids: Insights of Pathogenicity
Recent evidence indicates that viroid-derived small RNAs acting through host RNA silencing pathways play a key role in viroid pathogenicity.
Tobacco Mosaic Virus : Pioneering Research for a Century
artifactual aggregation involving CLV1.) Their intriguing hypothesis is that the CLV3 protein may in fact be the activating ligand of the CLV1 receptor kinase. This possibility is attractive in that
Anti-viral RNAi and its suppression in plants.
It was found that the hordeivirus protein γb contributes to enhancement of expression for the foreign protein GFP early in the plant defense, and studies involving Agrobacterium and virus-vectored cDNA to express green fluorescent protein (GFP) were used to establish that co introduced suppressors of RNAi can extend the production of a foreign protein for enhancement of biotechnological applications.
Inhibitory effects of Alpinia zerumbet extract against plant virus infection in solanaceous plants.
The extract of Alpinia plants has potential as an antiviral reagent for practical application in solanaceous crop production and the extracts of A. zerumbet isolated from Okinawa, locally referred to as shima-gettou, strongly inhibited ToMV and TMV infection.
Application of Machine Learning in Analysis of Transcriptomic Data Derived from Next Generation Sequencing
This research analyzes the time-series raw data and adapts the Fast Correlation-Based Filter and the Wrapper algorithms for gene selection to find out the genes related to replication of the Tobacco Mosaic Virus.


Tobacco Mosaic Virus The History of Tobacco Mosaic Virus and the Evolution of Molecular Biology
It was particularly the development of the ultracentrifuge and of the electron microscope that confirmed the existence of filtrable infectivity, and gave definitive information about the size and shape of viruses.
In 1885 Mr. Adolf Mayer2 showed that the mosaic or leaf-spot” disease of the tobacco plant is contagious. He pressed the sap from diseased plants, introduced it into capillary tubes, and pierced
One hundred years of virology
One hundred years ago a young Russian scientist, Dimitri Ivanovsky (1864 to 1920), presented a paper before the Academy of Sciences of St. Petersburg in which he stated that "the sap of leaves
Uber die Mosaikkrankheit der Tabakspflanze . Zeit . Pflanzenkr . Pflanzenpathol
  • Pflanzenschutz
  • 1903
Concerning the mosaic disease of the tobacco plant
  • St. Petersb. Acad.Imp. Sci. Bul
  • 1942
Untitled editorial
  • Arch. Virol
  • 1995