The Discovery of Vitamin C

@article{Carpenter2012TheDO,
  title={The Discovery of Vitamin C},
  author={Kenneth J. Carpenter},
  journal={Annals of Nutrition and Metabolism},
  year={2012},
  volume={61},
  pages={259 - 264}
}
  • K. Carpenter
  • Published 1 November 2012
  • Medicine
  • Annals of Nutrition and Metabolism
The term ‘scurvy’ for the disease resulting from prolonged vitamin C deficiency had origins in ‘scorbutus’ (Latin), ‘scorbut’ (French), and ‘Skorbut’ (German). Scurvy was a common problem in the world’s navies and is estimated to have affected 2 million sailors. In 1747, James Lind conducted a trial of six different treatments for 12 sailors with scurvy: only oranges and lemons were effective in treating scurvy. Scurvy also occurred on land, as many cases occurred with the ‘great potato famine… 

Vitamin C biochemistry: From scurvy to COVID-19 treatment

The story of vitamin C (L-ascorbic acid) as an antioxidant and a cofactor in numerous biochemical reactions is a part of its long history and it is well known today. However, many questions of its

A Review on Biological Functions and Sources of Anti-scorbutic Factor: Vitamin C

Vitamin C is a water soluble vitamin which subsume antioxidant action, a cofactor in enzymatic activity, enhancing iron absorption, pivotal role in immunity, regeneration of vitamin E, etc.

Vitamins, Biopigments, Antioxidants and Related Compounds: A Historical, Physiological and (Bio)technological Perspective

In hindsight, the history of organic compounds that are now called vitamins can be traced back to the ancient Egyptians; they experienced that feeding animal liver to a person would help cure night

The medicinal value and the numerous sources of vitamin c - a review

Polish biochemist Kazimierz Funk while working on experimental beriberi, gave the name “Vitaimine” from the words vital and amine meaning amine of life but then later the word “Vitamin” was

Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review

Despite promising observations, there are few observational and interventional studies, and their results do not clearly define the benefits of a high daily intake of vitamin C in preventing the development and recurrence of gout.

Ancient Bruises: a Case of Skin Lesions due to Vitamin C Deficiency

The case of a 63-year-old woman who presented with fatigue, nausea and progressive skin lesions consisting of multiple ecchymoses on the legs as also described in the diary drawings of a navy doctor in the 19th century is reported.

8. Vitamin C, scurvy, inflammation and cancer

The acute phase response is discussed, which is a systemic inflammatory response due to any type of aggression to the body (trauma, infection, cancer, autoimmune diseases), emphasizing the alterations in the serum levels of vitamins occurring during this response, especially vitamin C, that may lead to the onset of diseases due to hypovitaminosis.

Introduction: The Diverse and Essential Biological Functions of Vitamins

One hundred years ago, in 1912, the Polish-American scientist Casimir Funk coined the term ‘vitamine’ to describe a group of bioactive substances the authors now know to be essential for human health – a pivotal discovery that has contributed to a century of innovative research and improved health.

Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

The effects of vitamin C treatment in cancer prevention and the role of ascorbate in maintaining redox balance in the central nervous system (CNS) are discussed and the evidence that vitamin C has radioprotective properties is reviewed.
...

References

SHOWING 1-10 OF 27 REFERENCES

Hexuronic Acid as the Antiscorbutic Factor

AT the wish and by the courtesy of Prof. A. Szent-Györgyi, I arranged to examine in my laboratory the ‘hexuronic acid’ which he isolated while working in the Biochemical Laboratory, Cambridge. At the

The history of scurvy and vitamin C

To understand the essence of the midwife debate in the USA from 1800 to 1980 is far from easy; but to do so is to appreciate the breadth of the factors which have shaped obstetric care in the Western world.

Malaria as an Occupational Disease

It is demanded that malaria should be added to the list of occupational diseases in France for the following reasons: first, to repair the material damage to which a variety of workers are liable, namely, colonials and labourers in the veldt or canals, and secondly, for the adoption of additional prophylactic measures in conditions and localities where the work involves the risk of contracting malaria.

Experimental Studies Relating to Ship-beri-beri and Scurvy. II. On the Etiology of Scurvy

  • A. Holst
  • Medicine
    Epidemiology and Infection
  • 1907
It is found that guinea-pigs also contract a disease, and that this disease is accompanied by very characteristic changes.

Scurvy produced by a Zen macrobiotic diet.

A woman who embraced a Zen macrobiotic philosophy with its rigid nutritional system was completely bedridden and near death with the classical manifestations of scurvy and severe folic acid and

Hexuronic Acid as the Antiscorbutic Factor

A CHARACTERISTIC property of Prof. Szent-Györgyi's hexuronic acid is its behaviour towards iodine. Two atoms of iodine are taken up in aqueous solution (neutral or acid) with formation of two

OBSERVATIONS ON THE FUNCTION OF PEROXIDASE SYSTEMS AND THE CHEMISTRY OF THE ADRENAL CORTEX . DESCRIPTION OF A NEW CARBOHYDRATE DERIVATIVE

Evidence is presented in the present paper that the adrenal cortex is connected in some way with this dxidising mechanism.

Constitution of Ascorbic Acid

WE have now confirmed the accuracy of the structure (I) cooH.co.co.CHOH.CHOH.CH2OH which we had previously assigned to the first (reversible) oxidation product of ascorbic acid on the ground that it

Observations on the function of peroxidase systems and the chemistry of the adrenal cortex: Description of a new carbohydrate derivative.

During the first year of his fellowship at Cambridge, Szent-Gyorgyi was able to isolate the reducing substance he had found in earlier work with adrenal glands from orange and cabbage juice, and found that it was a carbohydrate, perhaps a sugar acid, but needed to name it before he published his results.

On the Nature, Cause, and Prevention of Scurvy

  • A. Garrod
  • Monthly Journal of Medical Science
  • 1848