The Discovery of Glycated Hemoglobin A Major Event in the Study of Nonenzymatic Chemistry in Biological Systems

@inproceedings{RAHBAR2005TheDO,
  title={The Discovery of Glycated Hemoglobin A Major Event in the Study of Nonenzymatic Chemistry in Biological Systems},
  author={SAMUEL RAHBAR},
  year={2005}
}
  • SAMUEL RAHBAR
  • Published 2005
Glycated hemoglobins are minor components of human hemoglobin (Hb). These are formed nonenzymatically by condensation of glucose or other reducing sugars with and -chains of hemoglobin A. The subfraction HbA1c, a nonenzymatic glycation at the amino-terminal valines of the β-chain, was identified by the author in the 1960s as a minor “abnormal fast-moving hemoglobin band” in diabetic patients during routine screening for hemoglobin variants. This finding later turned out to be an important… CONTINUE READING