The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis

@inproceedings{Hunter2016TheDE,
  title={The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis},
  author={Samuel F. Hunter and J D Bowen and Anthony T. Reder},
  booktitle={CNS drugs},
  year={2016}
}
Fingolimod, a structural analog of sphingosine derived from fungal metabolites, is a functional antagonist of the G-protein-coupled sphingosine 1-phosphate (S1P) receptors S1P(1,3,4,5). In the treatment of relapsing forms of multiple sclerosis (RMS), fingolimod acts by reversibly retaining central memory T cells and naïve T cells in lymph nodes, thereby reducing the recirculation of autoreactive lymphocytes to the central nervous system (CNS). Fingolimod also has differential effects on the… CONTINUE READING