The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection

  title={The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection},
  author={Deborah M. Brown and Anna T. Lampe and Aspen M. Workman},
  booktitle={Front. Immunol.},
CD4 T cells that recognize peptide antigen in the context of class II MHC can differentiate into various subsets that are characterized by their helper functions. However, increasing evidence indicates that CD4 cells with direct cytolytic activity (CD4 CTL) play a role in chronic as well as acute infections, such as influenza A virus (IAV) infection. In the last couple of decades, techniques to measure the frequency and activity of these cytolytic cells has demonstrated their abundance in… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS


Publications citing this paper.
Showing 1-9 of 9 extracted citations


Publications referenced by this paper.
Showing 1-10 of 57 references

Inflammation regulates the differentiation of CD4 T cells with cytolytic potential

DM Brown, AM Workman, AJ Vogel, S. Condon
J Immunol • 2013
View 14 Excerpts
Highly Influenced

MHC class II-restricted killing in vivo during viral infection

ER Jellison, SK Kim, edge Welsh RM. Cutting
J Immunol • 2005
View 4 Excerpts
Highly Influenced

Characterization of CD4(+) CTLs ex vivo.

Journal of immunology • 2002
View 7 Excerpts
Highly Influenced

Fas-dependent CD4+ cytotoxic T-cell-mediated pathogenesis during virus infection.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…