The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection

@inproceedings{Brown2016TheDA,
  title={The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection},
  author={Deborah M. Brown and Anna T. Lampe and Aspen M. Workman},
  booktitle={Front. Immunol.},
  year={2016}
}
CD4 T cells that recognize peptide antigen in the context of class II MHC can differentiate into various subsets that are characterized by their helper functions. However, increasing evidence indicates that CD4 cells with direct cytolytic activity (CD4 CTL) play a role in chronic as well as acute infections, such as influenza A virus (IAV) infection. In the last couple of decades, techniques to measure the frequency and activity of these cytolytic cells has demonstrated their abundance in… CONTINUE READING
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