The Differential Diagnosis of Parkinson’s Disease

@article{Greenland2018TheDD,
  title={The Differential Diagnosis of Parkinson’s Disease},
  author={Julia C Greenland and Roger A. Barker},
  journal={Parkinson’s Disease: Pathogenesis and Clinical Aspects},
  year={2018}
}
  • J. Greenland, R. Barker
  • Published 21 December 2018
  • Psychology, Biology, Medicine
  • Parkinson’s Disease: Pathogenesis and Clinical Aspects
ABSTRACT Parkinson’s disease (PD) is a common, progressive neurodegenerative disease. It is a movement disorder presenting primarily with a combination of bradykinesia, rigidity and tremor. However, it has a variable presentation, includ­ing the presence of non-motor symptoms such as cognitive impairment and sleep disturbance. The diagnosis is made clinically by the recognition of these key fea­tures and the exclusion of other causes of parkinsonism. This chapter describes how to recognize the… 

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References

SHOWING 1-10 OF 64 REFERENCES
Parkinson's disease: chameleons and mimics
TLDR
An overview of the diagnosis of PD and its most important chameleons and mimics is given, and the recent advances in structural and functional imaging in parkinsonism are reviewed.
Parkinson’s disease: clinical features and diagnosis
  • J. Jankovic
  • Medicine, Psychology
    Journal of Neurology, Neurosurgery, and Psychiatry
  • 2008
TLDR
A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.
Non-motor symptoms of Parkinson's disease: diagnosis and management
Vascular parkinsonism--an important cause of parkinsonism in older people.
TLDR
Parkinsonism due to cerebrovascular disease (vascular parkinsonism, VP) is a distinct clinicopathological entity and generally considered to be poorly or non-responsive to L-dopa therapy, however, recent studies have shown a beneficial effect of L- dopa in a subset of patients.
Diagnosis and treatment of psychogenic parkinsonism
  • J. Jankovic
  • Psychology, Medicine
    Journal of Neurology, Neurosurgery & Psychiatry
  • 2011
TLDR
A comprehensive, multidisciplinary assessment of patients with PP, when combined with insight oriented psychotherapy, physiotherapy and treatment of comorbid depression, is often helpful, although the prognosis for this group of disorders remains relatively poor.
Magnetic resonance imaging for the diagnosis of Parkinson’s disease
TLDR
This review aims to summarize research findings regarding the value of the different MRI techniques, including advanced sequences at high- and ultra-high-field MRI and modern image analysis algorithms, in the diagnostic work-up of Parkinson’s disease.
MDS clinical diagnostic criteria for Parkinson's disease
  • R. Postuma, D. Berg, G. Deuschl
  • Psychology, Medicine
    Movement disorders : official journal of the Movement Disorder Society
  • 2015
TLDR
The Movement Disorder Society PD Criteria retain motor parkinsonism as the core feature of the disease, defined as bradykinesia plus rest tremor or rigidity, and two levels of certainty are delineated: clinically established PD and probable PD.
Drug-Induced Parkinsonism
TLDR
DIP may have a significant and longstanding effect on patients' daily lives, and so physicians should be cautious when prescribing dopaminergic receptor blockers and should monitor patients' neurological signs, especially for parkinsonism and other movement disorders.
Nonmotor symptoms as presenting complaints in Parkinson's disease: A clinicopathological study
TLDR
Nonmotor symptoms are commonly seen as presenting complaints in pathologically confirmed PD, and initial misdiagnosis may be associated with potentially inappropriate medical interventions.
A clinicopathologic study of 100 cases of Parkinson's disease.
TLDR
The clinical details of 100 cases of histologically confirmed Parkinson's disease were examined and correlated with pathologic findings, finding the general pattern of disease conformed to traditional descriptions, and the findings broaden the present clinical and pathologic spectrum of Parkinson's Disease.
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