The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry–Biology Interface

  title={The Difference a Single
Atom Can Make: Synthesis and
Design at the Chemistry–Biology Interface},
  author={D. Boger},
  booktitle={The Journal of organic chemistry},
  • D. Boger
  • Published in
    The Journal of organic…
  • Chemistry, Medicine
A Perspective of work in our laboratory on the examination of biologically active compounds, especially natural products, is presented. In the context of individual programs and along with a summary of our work, selected cases are presented that illustrate the impact single atom changes can have on the biological properties of the compounds. The examples were chosen to highlight single heavy atom changes that improve activity, rather than those that involve informative alterations that reduce… Expand
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