The Dictyostelium Bcr/Abr-related protein DRG regulates both Rac- and Rab-dependent pathways.

@article{Knetsch2001TheDB,
  title={The Dictyostelium Bcr/Abr-related protein DRG regulates both Rac- and Rab-dependent pathways.},
  author={Menno L. W. Knetsch and N Schaefers and H. Horstmann and Dietmar J Manstein},
  journal={The EMBO journal},
  year={2001},
  volume={20 7},
  pages={1620-9}
}
Dictyostelium discoideum DdRacGap1 (DRG) contains both Rho-GEF and Rho-GAP domains, a feature it shares with mammalian Bcr and Abr. To elucidate the physiological role of this multifunctional protein, we characterized the enzymatic activity of recombinant DRG fragments in vitro, created DRG-null cells, and studied the function of the protein in vivo by… CONTINUE READING