The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formation.

@article{Untergasser2007TheD3,
  title={The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formation.},
  author={Gerold Untergasser and Michael A. Steurer and Martina Zimmermann and Martin Hermann and Johann Kern and Albert Amberger and Guenther Gastl and Eberhard Gunsilius},
  journal={International journal of cancer},
  year={2007},
  volume={122 7},
  pages={
          1539-47
        }
}
A critical event in tumor growth and progression is the upregulation of angiogenesis. Thus, targeting angiogenesis has become an attractive treatment modality in cancer medicine. Our study analyzed various solid tumor types for the expression of Dkk-3, a cystein-rich, N-glycosylated secreted member of the Dickkopf protein family that has been proposed as a tumor suppressor gene. Tissue microarrays of gliomas (n = 30), high-grade non-Hodgkin's lymphomas (NHL, n = 80), colorectal cancer (n = 35… CONTINUE READING
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