The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.

@article{Hannemann2008TheDF,
  title={The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.},
  author={Sebastian Hannemann and Ricardo Madrid and Jana Stastna and Thomas Kitzing and Judith E. Gasteier and Andr{\'e} Sch{\"o}nichen and J{\'e}r{\^o}me Bouchet and Alberto Jim{\'e}nez and Matthias Geyer and Robert Grosse and Serge B{\'e}nichou and Oliver T. Fackler},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 41},
  pages={27891-903}
}
Diaphanous-related formins (DRFs) mediate GTPase-triggered actin rearrangements to regulate central cellular processes, such as cell motility and cytokinesis. The DRF FHOD1 interacts with the Rho-GTPase Rac1 and mediates formation of actin stress fibers in its deregulated form; the physiologically relevant activities and molecular mechanisms of endogenous FHOD1, however, are still unknown. Here we report that FHOD1 physically associates via the N-terminal part of its FH2 domain with the central… CONTINUE READING

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