The Diagnostic Accuracy of Fecal Calprotectin During the Investigation of Suspected Pediatric Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

@article{Henderson2014TheDA,
  title={The Diagnostic Accuracy of Fecal Calprotectin During the Investigation of Suspected Pediatric Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis},
  author={Paul Henderson and Niall H. Anderson and David C. Wilson},
  journal={The American Journal of Gastroenterology},
  year={2014},
  volume={109},
  pages={637-645}
}
OBJECTIVES:Fecal calprotectin (FC) is increasingly used during the diagnosis of inflammatory bowel disease (IBD), outperforming blood markers during investigation in children. Tests that reduce endoscopy rates in children with suspected gut inflammation would be beneficial. We aimed to determine the usefulness of FC in children undergoing their primary investigation for suspected IBD by systematic review and meta-analysis.METHODS:An electronic search was performed with keywords relating to IBD… Expand
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TLDR
Recent publications about the role and limitations of FCAL in IBD are summarized, with a special focus on meta-analyses, and an overview of alternative faecal biomarkers are given. Expand
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TLDR
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TLDR
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TLDR
Although FC alone is a useful screening test for IBD, a normal FC alone does not exclude IBD and extending FC to include albumin or platelet count may improve sensitivity, specificity, PPV and NPV in diagnosing IBD. Expand
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TLDR
Adding fecal calprotectin to the diagnostic workup of pediatric patients with symptoms suggestive of IBD considerably decreased the number of patients in the group in whom challenges in clinical decision making are most prevalent. Expand
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TLDR
Significantly increased levels of six different fecal amino acids were found in patients with IBD compared to controls, whether these differences reflect decreased absorption or increased loss by inflamed intestines needs to be elucidated. Expand
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TLDR
All three tests are very sensitive for detecting mucosal inflammation, but major differences exist between specificity and absolute values. Expand
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This study demonstrates that FC is an invaluable tool in determining those children who may require endoscopy for suspected IBD, and elevated values should prompt further investigation. Expand
Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis
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Testing for faecal calprotectin is a useful screening tool for identifying patients who are most likely to need endoscopy for suspected inflammatory bowel disease and the discriminative power to safely excludeinflammatory bowel disease was significantly better in studies of adults than in studies in children. Expand
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