The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview

@article{Nathan2013TheDC,
  title={The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview},
  author={David M. Nathan},
  journal={Diabetes Care},
  year={2013},
  volume={37},
  pages={9 - 16}
}
  • D. Nathan
  • Published 11 December 2013
  • Medicine
  • Diabetes Care
OBJECTIVE The Diabetes Control and Complications Trial (DCCT) was designed to test the glucose hypothesis and determine whether the complications of type 1 diabetes (T1DM) could be prevented or delayed. The Epidemiology of Diabetes Interventions and Complications (EDIC) observational follow-up determined the durability of the DCCT effects on the more-advanced stages of diabetes complications including cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS The DCCT (1982–1993) was a… Expand

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With the comprehensive data collection and the remarkable participant retention over 30 years, the DCCT/EDIC continues as an irreplaceable resource for understanding type 1 diabetes and its long-term complications. Expand
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Advances and Contributions
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DCCT INT and the attendant 6.5 years of lower HbA1c had long-term salutary effects on the development and progression of atherosclerosis and cardiovascular disease during the subsequent follow-up during EDIC. Expand
Kidney Disease and Related Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
TLDR
In the DCCT/EDIC, intensive diabetes therapy aimed at lowering glucose concentrations as close as safely possible to the normal range reduces the risks of kidney disease and other diabetes complications, and resulted in clinically important, durable reductions in the risk of microalbuminuria, macroalbuminia, impaired GFR, and hypertension. Expand
Kidney Disease and Related Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
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In the DCCT/EDIC, intensive diabetes therapy aimed at lowering glucose concentrations as close as safely possible to the normal range reduces the risks of kidney disease and other diabetes complications, and resulted in clinically important, durable reductions in the risk of microalbuminuria, macroalbuminia, impaired GFR, and hypertension. Expand
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Celebrating 30 Years of Research Accomplishments of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
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The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Summary and Future Directions
TLDR
With the comprehensive data collection and the remarkable participant retention over 30 years, the DCCT/EDIC continues as an irreplaceable resource for understanding type 1 diabetes and its long-term complications. Expand
Update on Cardiovascular Outcomes at 30 Years of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
TLDR
DCCT INT and the attendant 6.5 years of lower HbA1c had long-term salutary effects on the development and progression of atherosclerosis and cardiovascular disease during the subsequent follow-up during EDIC. Expand
Kidney Disease and Related Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
TLDR
In the DCCT/EDIC, intensive diabetes therapy aimed at lowering glucose concentrations as close as safely possible to the normal range reduces the risks of kidney disease and other diabetes complications, and resulted in clinically important, durable reductions in the risk of microalbuminuria, macroalbuminia, impaired GFR, and hypertension. Expand
Kidney Disease and Related Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
TLDR
In the DCCT/EDIC, intensive diabetes therapy aimed at lowering glucose concentrations as close as safely possible to the normal range reduces the risks of kidney disease and other diabetes complications, and resulted in clinically important, durable reductions in the risk of microalbuminuria, macroalbuminia, impaired GFR, and hypertension. Expand
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TLDR
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TLDR
The participants, compared with nonparticipants, tended to have better glycemic control at the completion of the D CCT and were more likely to have their diabetes care provided by DCCT personnel and the quality of EDIC data is very similar to that observed in the DCCt. Expand
Diabetes Control and Complications Trial (DCCT): Results of Feasibility Study. The DCCT Research Group
TLDR
The feasibility phase of the DCCT demonstrated that a complex multicenter, randomized study of the relationship between diabetes control and complications can be performed, and the full-scale, long-term trial therefore has been initiated. Expand
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC)
TLDR
DCCT/EDIC provides long-term, objective documentation of glycaemic control and its relationship to cardiovascular complications, however, until methods of bringing down HbA1c% without the added problem of frequent hypoglycaemia are found, it may find it difficult to translate these findings into everyday practice. Expand
The Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
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Waist-to-hip ratio, smoking, hypertension, and hypercholesterolemia, before or at the time of CT, were significantly associated with CAC in univariate and multivariate analyses and CAC was associated with mean HbA1c levels before enrollment, during the DCCT, and during the EDIC study. Expand
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The DCCT proved that intensive treatment reduced the risks of retinopathy, nephropathy, and neuropathy by 35% to 90% compared with conventional treatment, and the benefits of 6.5 years of intensive treatment extend well beyond the period of its most intensive implementation. Expand
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