The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP.

  title={The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP.},
  author={Pablo Cabrero and Jonathan C. Radford and Kate E Broderick and Laurence Costes and Jan A Veenstra and Eric P. Spana and Shireen A. Davies and Julian A. T. Dow},
  journal={The Journal of experimental biology},
  volume={205 Pt 24},
Dh, the gene that encodes a CRF-like peptide in Drosophila melanogaster, is described. The product of this gene is a 44-amino-acid peptide (Drome-DH(44)) with a sequence almost identical to the Musca domestica and Stomoxys calcitrans diuretic hormones. There are no other similar peptides encoded within the known Drosophila genomic sequence. Functional studies showed that the deduced peptide stimulated fluid production, and that this effect was mediated by cyclic AMP in principal cells only… CONTINUE READING
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Two new members of the CAP 2 b family of diuretic peptides are encoded by the gene capability in Drosophila melanogaster

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