The Development of a Biotinylated NAD+-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay

@article{Ji2018TheDO,
  title={The Development of a Biotinylated NAD+-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay},
  author={Ming Ji and Liyuan Wang and Nina Xue and Fangfang Lai and Sen Zhang and Jing Jin and Xiaoguang Chen},
  journal={SLAS Discovery},
  year={2018},
  volume={23},
  pages={545 - 553}
}
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. The biological roles of PARP3 are currently under investigation; however, several key reports indicate the integral roles of PARP3 in DNA damage repair, and thus it has been investigated as a novel target in oncology. It is clear that the identification of selective PARP3 inhibitors would further advance the understanding of the biological roles of… Expand
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Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes
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