The Development of Neutrophilic Polymorphonuclear Leukocytes in Human Bone Marrow

  title={The Development of Neutrophilic Polymorphonuclear Leukocytes in Human Bone Marrow},
  author={Dorothy Ford Bainton and Joan L. Ullyot and Marilyn Gist Farquhar},
  journal={The Journal of Experimental Medicine},
  pages={907 - 934}
Neutrophilic leukocytes (PMN) and their precursors from normal human marrow and blood were examined by histochemical staining and by electron microscopy and cytochemistry in order to determine the origin and nature of their cytoplasmic granules. Human neutrophils contain two basic types of granules, azurophils and specifics, which differ in morphology, contents, and time of origin. Azurophils are large and may be spherical or ellipsoid, the latter with a crystalline inclusion. They are produced… CONTINUE READING
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