The Development of Cannabinoid Antagonists

@article{Barth1999TheDO,
  title={The Development of Cannabinoid Antagonists},
  author={Francis Barth and Murielle Rinaldi-Carmona},
  journal={Current Medicinal Chemistry},
  year={1999}
}
The discovery of two distinct cannabinoid receptors (CB1 and C B 2 ) in the early 1990's has revived the research on cannabinoid antagonists. While the search for antagonists based on the structure of agonists (classical cannabinoids or aminoalkylindoles) appeared rather disappointing, the first potent cannabinoid antagonists were developed in a new chemical series: the diarylpyrazoles. Since its discovery in 1994, the selective CB1 antagonist SR 141716 has become a major pharmacological tool… 
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The development of cannabinoid antagonists.
TLDR
The discovery of two distinct cannabinoid receptors (CB1 and CB2) in the early 1990's has revived the research on cannabinoid antagonists, and the first potent cannabinoid antagonists were developed in a new chemical series: the diarylpyrazoles.