The Development of β-Lactam Antibiotics in Response to the Evolution of β-Lactamases

@article{Essack2004TheDO,
title={The Development of $\beta$-Lactam Antibiotics in Response to the Evolution of $\beta$-Lactamases},
author={Sabiha Yusuf Essack},
journal={Pharmaceutical Research},
year={2004},
volume={18},
pages={1391-1399}
}
• S. Essack
• Published 1 October 2001
• Biology, Chemistry
• Pharmaceutical Research
Abstractβ-Lactam antibiotics, viz., penicillin, penicillin derivatives, cephalosporins, cephamycins, carbapenems, monobactams, and monocarbams, are the most widely used of all antimicrobial classes by virtue of their high efficacy and specificity and the availability of several derivatives. The expression of one or several β-lactamases (β-lactam antibiotic-inactivating enzymes) represents the most widespread and the most clinically relevant resistance mechanism to these antibiotics. The…
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