The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. DENIS Group.

@article{Lampeter1998TheDN,
  title={The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. DENIS Group.},
  author={E. F. Lampeter and Albrecht Klinghammer and Werner Alfred Scherbaum and Eberhard Heinze and Burkhart Haastert and G. Giani and Hubert Kolb},
  journal={Diabetes},
  year={1998},
  volume={47 6},
  pages={980-4}
}
On the basis of the positive outcome of animal experiments, several large placebo-controlled trials are underway and aiming for the first time at the prevention of an immune-mediated disease, type 1 diabetes. The first of these trials, The Deutsche Nicotinamide Intervention Study (DENIS), evaluated the clinical efficacy of high doses of nicotinamide in children at high risk for IDDM. Nicotinamide has been shown to protect beta-cells from inflammatory insults and to improve residual beta-cell… CONTINUE READING
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