The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.

@article{Nelson2016TheDU,
  title={The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.},
  author={Jessica Kristine Nelson and Vincenzo Sorrentino and Rossella Avagliano Trezza and Claire Heride and Sylvie Urb{\'e} and B. Distel and Noam Zelcer},
  journal={Circulation research},
  year={2016},
  volume={118 3},
  pages={410-9}
}
RATIONALE The low-density lipoprotein (LDL) receptor (LDLR) is a central determinant of circulating LDL-cholesterol and as such subject to tight regulation. Recent studies and genetic evidence implicate the inducible degrader of the LDLR (IDOL) as a regulator of LDLR abundance and of circulating levels of LDL-cholesterol in humans. Acting as an E3-ubiquitin ligase, IDOL promotes ubiquitylation and subsequent lysosomal degradation of the LDLR. Consequently, inhibition of IDOL-mediated… CONTINUE READING
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