The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity

@article{GarcaCaballero2014TheDE,
  title={The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity},
  author={Agustin Garc{\'i}a-Caballero and Vin{\'i}cius de Maria Gadotti and Patrick L. Stemkowski and Norbert Weiss and Ivana Assis Souza and Victoria Hodgkinson and Chris Bladen and Lina Chen and Jawed Hamid and Anne Pizzoccaro and Mickael Deage and Amaury François and Emmanuel Bourinet and Gerald W Zamponi},
  journal={Neuron},
  year={2014},
  volume={83},
  pages={1144-1158}
}
T-type calcium channels are essential contributors to the transmission of nociceptive signals in the primary afferent pain pathway. Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3.2 T-type channel and modifies specific lysine residues in this region. A proteomic screen identified the deubiquitinating enzyme USP5 as a Cav3.2 III-IV linker interacting partner… CONTINUE READING
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