The Design of Integrated Circuits to Observe Brain Activity

@article{Harrison2008TheDO,
  title={The Design of Integrated Circuits to Observe Brain Activity},
  author={Reid R. Harrison},
  journal={Proceedings of the IEEE},
  year={2008},
  volume={96},
  pages={1203-1216}
}
  • R. Harrison
  • Published 17 June 2008
  • Engineering
  • Proceedings of the IEEE
The ability to monitor the simultaneous electrical activity of multiple neurons in the brain enables a wide range of scientific and clinical endeavors. Recent efforts to merge miniature multielectrode neural recording arrays with integrated electronics have revealed significant circuit design challenges. Weak neural signals must be amplified and filtered using low-noise circuits placed close to the electrodes themselves, but power dissipation must strictly be limited to prevent tissue damage… 

Modeling, Design and Test of an Integrated Optical Neural Recording Device

It has long been a goal of neuroscientists to understand how electrophysiological activity in the nervous system corresponds to, and causes, specific physiological actions. Such knowledge could be

A flexible clockless 32-ch simultaneous wireless neural recording system with adjustable resolution

  • M. YinMaysam Ghovanloo
  • Computer Science
    2009 IEEE International Solid-State Circuits Conference - Digest of Technical Papers
  • 2009
TLDR
Neuroscientists are interested in replacing the wire bundles with a wireless link and continue recording and processing the “entire” neural signals in their high-performance computing clusters without losing any information.

Low Power Programmable Gain Analog to Digital Converter for Integrated Neural Implant Front End

TLDR
This chapter describes the noise fluctuations on a circuit-architecture level for efficient hardware implementation of programmable gain analog to digital converter for neural signal-processing and provides key insight required to address signal-to-noise ratio, response time, and linearity of the physical electronic interface.

Systematic design of a programmable low-noise CMOS neural interface for cell activity recording

TLDR
The systematic design of a programmable low-noise multi-channel neural interface that can be used for the recording of neural activity in in vitro and in vivo experiments is presented and simultaneous recordings of action potential signals are performed.

Low-Gain, Low-Noise Integrated Neuronal Amplifier for Implantable Artifact-Reduction Recording System

TLDR
A low-gain, low-noise integrated neuronal amplifier (NA) with the capability of recording local field potentials (LFP) and spike activity is presented and ability of the NA to perform spike recording in test-bench experiments is presented.

Sensor signal conditioning circuit design for multi-electrode intra-cortical recording

Brain-Machine Interfaces (BMIs) have been developed in the pa st few decades to establish a bridge between brain and external electronic s and computing devices. Driven by an increasing demand in

A 256-input micro-electrode array with integrated CMOS amplifiers for neural signal recording

TLDR
An active microelectrode arrays (MEAs) with amplifiers integrated on the same substrate are used because they provide a very powerful neural electrical recording technique that can be directly interfaced to acute slices and cell cultures.

Noise Analysis of Programmable Gain Analog to Digital Converter for Integrated Neural Implant Front End

TLDR
This paper characterize the noise fluctuations on a circuit-architecture level for efficient hardware implementation of programmable gain analog to digital converter for neural signal-processing.

Active C4 Electrodes for Local Field Potential Recording Applications

TLDR
A 4 mm × 4 mm neural recording integrated circuit (IC) chip, utilizing IBM C4 bumps as recording electrodes, which enable a seamless active chip and electrode integration and is scalable for implementing larger number and higher density electrode arrays.

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

TLDR
By combining nanofabricated probes with ASICs, this work has implemented a system for performing large-scale, high-density electrophysiology in small, freely behaving animals that is both minimally invasive and highly scalable.
...

References

SHOWING 1-10 OF 77 REFERENCES

A low-power integrated circuit for adaptive detection of action potentials in noisy signals

  • R. Harrison
  • Computer Science
    Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439)
  • 2003
TLDR
An algorithm to perform real-time data reduction by detecting action potentials, or "spikes," embedded in a noisy signal by being implemented in a mixed-signal integrated circuit consuming less than 60 /spl mu/W of power.

Local field potential measurement with low-power analog integrated circuit

TLDR
A low-power, fully-integrated circuit that performs on-site data reduction by isolating LFPs and measuring their signal energy is presented and it is shown that the chip performs similarly to state-of-the-art signal processing algorithms.

An implantable multielectrode array with on-chip signal processing

This active probe can be used for the long-term recording of extracellular neural biopotentials and as a basis for closed-loop neural prostheses. The probe incorporates on-chip circuitry for

Wireless implantable microsystems: high-density electronic interfaces to the nervous system

TLDR
This paper describes the development of a high-density electronic interface to the central nervous system that permits the long-term monitoring of neural activity in vivo as well as the insertion of electronic signals into neural networks at the cellular level.

A low-power CMOS neural amplifier with amplitude measurements for spike sorting

TLDR
Low-power neural amplifiers with integrated pre-filtering and measurements of the spike signal to facilitate spike-sorting and data reduction prior to transmission to a data-acquisition system are developed.

High-quality recording of bioelectric events

TLDR
A multichannel instrumentation amplifier, developed to be used in a miniature universal eight-channel amplifier module, is described and the results of this study are applied to miniature, universal, eight- channel amplifier modules, manufactured with thick-film production techniques.

Power feasibility of implantable digital spike sorting circuits for neural prosthetic systems

TLDR
It is reported that state-of-the-art spike sorting algorithms are not only feasible using modern complementary metal oxide semiconductor very large scale integration processes, but may represent the best option for extracting large amounts of data in implantable neural prosthetic interfaces.

A three-dimensional microelectrode array for chronic neural recording

TLDR
A platform-based signal processing system has been designed to interface with several active probes, providing direct analog access to the recording sites, performing on-chip analog-to-digital conversion of neural activity, and providing simple binary-output recognition of single-unit spike events using a user-input threshold voltage.

In vitro and in vivo study of temperature increases in the brain due to a neural implant

TLDR
The thermal influence of the integrated 3-dimensional Utah electrode array (UEA) device implanted in the brain was investigated by experimental measurement in vitro as well as in vivo.

HermesB: A Continuous Neural Recording System for Freely Behaving Primates

TLDR
The utility of the HermesB system is demonstrated and the initial results suggest that spike-sorting algorithms can no longer assume stable neural signals and will need to transition to adaptive signal processing methodologies to maximize performance.
...