The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals

@article{Krause2007TheDF,
  title={The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals},
  author={Johannes Krause and Carles Lalueza-Fox and Ludovic Orlando and Wolfgang Enard and Richard E. Green and Hern{\'a}n A. Burbano and Jean-Jacques Hublin and Catherine H{\"a}nni and Javier Fortea and Marco de la Rasilla and Jaume Bertranpetit and Antonio Rosas and Svante P{\"a}{\"a}bo},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={1908-1912}
}
Study of Modern Human Evolution via Comparative Analysis with the Neanderthal Genome
TLDR
It is proposed that future comparative studies may include retrotransposons, pseudogenes, and conserved non-coding regions, all of which might have played significant roles during the evolution of modern humans.
The evolution of FOXP2 in the light of admixture
Paleogenomics of Archaic Hominins
The Timing of Selection at the Human FOXP2 Gene
TLDR
It is found that, depending on the assumptions, additional control experiments may be needed to rule out contamination at FOXP2 and this work introduces a modeling framework to estimate levels of modern human contamination of the Neanderthal samples.
Neanderthal genomics and the evolution of modern humans.
  • J. Noonan
  • Biology, Medicine
    Genome research
  • 2010
TLDR
Attempts to obtain genomic sequence from Neanderthal, the closest known relative of modern humans, are discussed and a reconstructed Neanderthal genome sequence could be integrated into human-primate genome comparisons to help reveal the evolutionary genetic events that produced modern humans.
A Draft Sequence of the Neandertal Genome
TLDR
The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.
Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture
TLDR
It is shown that hybridization capture on microarrays can successfully recover more than a megabase of target regions from Neandertal DNA even in the presence of ~99.8% microbial DNA.
Linkage disequilibrium extends across putative selected sites in FOXP2.
TLDR
Polymorphism data in humans suggest that the gene encoding the transcription factor FOXP2, which influences speech and language development, has been subject to a selective sweep within the last 260,000 years, and it is found that the haplotypes extend across the two sites.
Phylogenomic evidence of adaptive evolution in the ancestry of humans
TLDR
A phylogenomic assessment of being human should examine earlier stages of human ancestry as well as later stages, and similarities in phenotype between distantly related taxa should be explored for evidence of convergent or parallel adaptive evolution.
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