The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals

@article{Krause2007TheDF,
  title={The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals},
  author={Johannes Krause and Carles Lalueza-Fox and Ludovic Orlando and Wolfgang Enard and Richard E. Green and Hern{\'a}n A. Burbano and Jean-Jacques Hublin and Catherine H{\"a}nni and Javier Fortea and Marco de la Rasilla and Jaume Bertranpetit and Antonio Rosas and Svante P{\"a}{\"a}bo},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={1908-1912}
}
Although many animals communicate vocally, no extant creature rivals modern humans in language ability. Therefore, knowing when and under what evolutionary pressures our capacity for language evolved is of great interest. Here, we find that our closest extinct relatives, the Neandertals, share with modern humans two evolutionary changes in FOXP2, a gene that has been implicated in the development of speech and language. We furthermore find that in Neandertals, these changes lie on the common… Expand
No Evidence for Recent Selection at FOXP2 among Diverse Human Populations
TLDR
A substantial revision to the adaptive history of FOXP2, a gene regarded as vital to human evolution, is presented, finding an intronic region that is enriched for highly conserved sites that are polymorphic among humans, compatible with a loss of function in humans. Expand
Study of Modern Human Evolution via Comparative Analysis with the Neanderthal Genome
TLDR
It is proposed that future comparative studies may include retrotransposons, pseudogenes, and conserved non-coding regions, all of which might have played significant roles during the evolution of modern humans. Expand
The evolution of FOXP2 in the light of admixture
TLDR
One of the largest deserts of admixture encompasses FOXP2, suggesting incompatibilities between modern humans and other Homo lineages due to functional differences. Expand
Paleogenomics of Archaic Hominins
TLDR
The genomes provide a preliminary catalogue of derived amino acids that are specific to all extant modern humans, thus offering insights into the functional differences between the three lineages, and provide evidence of gene flow between thethree lineages after anatomically modern humans left Africa. Expand
The Timing of Selection at the Human FOXP2 Gene
TLDR
It is found that, depending on the assumptions, additional control experiments may be needed to rule out contamination at FOXP2 and this work introduces a modeling framework to estimate levels of modern human contamination of the Neanderthal samples. Expand
Neanderthal genomics and the evolution of modern humans.
  • J. Noonan
  • Biology, Medicine
  • Genome research
  • 2010
TLDR
Attempts to obtain genomic sequence from Neanderthal, the closest known relative of modern humans, are discussed and a reconstructed Neanderthal genome sequence could be integrated into human-primate genome comparisons to help reveal the evolutionary genetic events that produced modern humans. Expand
Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture
TLDR
It is shown that hybridization capture on microarrays can successfully recover more than a megabase of target regions from Neandertal DNA even in the presence of ~99.8% microbial DNA. Expand
A Draft Sequence of the Neandertal Genome
TLDR
The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other. Expand
Linkage disequilibrium extends across putative selected sites in FOXP2.
TLDR
Polymorphism data in humans suggest that the gene encoding the transcription factor FOXP2, which influences speech and language development, has been subject to a selective sweep within the last 260,000 years, and it is found that the haplotypes extend across the two sites. Expand
Phylogenomic evidence of adaptive evolution in the ancestry of humans
TLDR
A phylogenomic assessment of being human should examine earlier stages of human ancestry as well as later stages, and similarities in phenotype between distantly related taxa should be explored for evidence of convergent or parallel adaptive evolution. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Sequencing and Analysis of Neanderthal Genomic DNA
TLDR
The characterization of Neanderthals from a new perspective is described, based on the development of a Neanderthal metagenomic library and its high-throughput sequencing and analysis, and the finding that the Neanderthal and human genomes are at least 99.5% identical is found. Expand
Accelerated protein evolution and origins of human-specific features: Foxp2 as an example.
TLDR
An important role that FOXP2 may have played in the origin of human speech is suggested and a strategy for identifying candidate genes underlying the emergences of human-specific features is demonstrated. Expand
No Evidence of Neandertal mtDNA Contribution to Early Modern Humans
TLDR
The biomolecular preservation of four Neandertals and of five early modern humans was good enough to suggest the preservation of DNA, and in combination with current mtDNA data, this excludes any large genetic contribution by Ne andertals to early modern human humans, but does not rule out the possibility of a smaller contribution. Expand
Molecular evolution of FOXP2, a gene involved in speech and language
TLDR
It is shown that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution. Expand
Analysis of one million base pairs of Neanderthal DNA
TLDR
A 38,000-year-old Neanderthal fossil that is exceptionally free of contamination from modern human DNA is identified and it is revealed that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago. Expand
Genetic evidence for complex speciation of humans and chimpanzees
TLDR
This analysis shows that human–chimpanzee speciation occurred less than 6.3 million years ago and probably more recently, conflicting with some interpretations of ancient fossils and most strikingly, chromosome X shows an extremely young genetic divergence time, close to the genome minimum along nearly its entire length. Expand
Y chromosome sequence variation and the history of human populations
Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permittingExpand
Neandertal evolutionary genetics: mitochondrial DNA data from the iberian peninsula.
TLDR
An estimate of effective population size indicates that the genetic history of the Neandertals was not shaped by an extreme population bottleneck associated with the glacial maximum of 130,000 years ago and fits chronologically with a proposed speciation event of Homo neanderthalensis. Expand
Recent common ancestry of human Y chromosomes: evidence from DNA sequence data.
TLDR
It is estimated that the spread of Y chromosomes out of Africa is much more recent than previously was thought, and the data indicate substantial population growth in the effective number of human Y chromosomes. Expand
Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae
TLDR
The phylogenetic analyses show that the mammoth was more closely related to the Asian than to the African elephant, and the divergence of mammoth, African and Asian elephants occurred over a short time, corresponding to only about 7% of the total length of the phylogenetic tree for the three evolutionary lineages. Expand
...
1
2
3
4
...