The Deposition of Exogenous Copper under Experimental Conditions with Observations on Its Neurotoxic and Nephrotoxic Properties in Relation to Wilson's Disease

Abstract

Goldfish kept in water containing ionized copper and a detergent added with the aim of decreasing coagulation of the mucus on the gills, took in and retained this metal in their brains, livers, and kidneys, in concentrations comparable to those that occur naturally in Wilson's disease, as chemical assays disclosed. Histochemical studies made it clear that… (More)

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