The Depolarizing Action of GABA Controls Early Network Activity in the Developing Hippocampus

@article{Cherubini2010TheDA,
  title={The Depolarizing Action of GABA Controls Early Network Activity in the Developing Hippocampus},
  author={Enrico Cherubini and Marilena Griguoli and Victoria F. Safiulina and Laura Lagostena},
  journal={Molecular Neurobiology},
  year={2010},
  volume={43},
  pages={97-106}
}
Early in postnatal life γ-aminobutyric acid (GABA), the primary inhibitory transmitter in adults, excites targeted neurons by an outwardly directed flux of chloride which results from the unbalance between the cation–chloride cotransporters NKCC1 and KCC2, involved in chloride uptake and extrusion, respectively. This effect contributes to generate synchronized network activity or giant depolarizing potentials (GDPs) in the developing hippocampus. Here, we review some recent data concerning the… CONTINUE READING

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