The Dengue

  title={The Dengue},
  author={Dengue Richtlijn},
  journal={The Hospital},
  pages={344 - 345}
Synonyms. *?Dengue fever, dandy fever, broken wing, break-bone fever, break-heart fever. The word dengue means, in Spanish, affectation, and corresponds thus very well to many of the other names which have, in various languages, been given to the disease. The natural explanation of the term seems, therefore, to be that it has been introduced into other languages from Spanish, which transition would very easily have taken place, considering that Spain was the first country in Europe in which… 

Lichen-Derived Diffractaic Acid Inhibited Dengue Virus Replication in a Cell-Based System

It is highlighted that a lichen-derived diffractaic acid could become a mosquito-borne antiviral lead as its selectivity indices ranged from 8.07 to 20.59 with a proposed target at viral replication.

Humoral Immune Response Profile of COVID-19 Reveals Severity and Variant-Specific Epitopes: Lessons from SARS-CoV-2 Peptide Microarray

The study revealed severity-based epitopes that could be presented as potential prognostic serological markers for diagnosing variants responsible for the infection of SARS-CoV-2 and the mutant epitope immunogenicity could indicate the putative use of these markers.

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This review examines several emerging rapid and point-of-care diagnostic devices that hold significant potential for the progress in smart diagnosis tools and revealed that an effective vaccine is required urgently against all the dengue virus serotypes.

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Analysis using IEDB database indicates that 92 out of 151 predicetd peptides are novel, hitherto unreported peptides, and their subsequent identification will enhance the understanding of the disease pathogenesis and in the development of better vaccines.

Dengue: A Minireview

This work reviews DENV biology, epidemiology, transmission dynamics including circulating serotypes and genotypes, the immune response, the pathogenesis of the disease as well as updated diagnostic methods, treatments, vector control and vaccine developments.

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This essay further problematizes the supposed dominance of the laboratory and the microscope in normalizing disease at the turn of the nineteenth and twentieth centuries by examining scientific images produced in the study of dengue fever in Asia.

Screening of Potential Northern African Natural Product Compounds as Dengue Virus NS5 Methyltransferase Inhibitor: An in Silico Approach

From the docking simulations, three ligands showed favorable inhibition activities by having lower ΔGbinding value than the standard ligands, and can be suggested as drug candidates for treating DENV infection by targeting SAH-binding site of NS5 MTase.

Dengue proteins with their role in pathogenesis, and strategies for developing an effective anti‐dengue treatment: A review

The systematic understanding of all dengue proteins, role of its structural proteins in virus entry, assembly, and secretion in host cell, and nonstructural proteins in viral assembly, replication, and immune evasion during d Dengue progression and pathogenesis are provided.

Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study

These findings demonstrated the potential of mushroom extracts as anti-dengue therapeutic agents with less toxic effects and a marked reduction in the expression levels of the ENV and NS5 genes in the simultaneous and penetration assays of the ASEs and HAEs.



Construction of a full length infectious clone for dengue-1 virus Western Pacifi c,74 strain. Virus Gene

  • 2000

Construction of a dengue virus type 4 reporter replicon and analysis of temperature-sensitive mutations in non-structural proteins 3 and 5

This study constructed a dengue virus 4 replicon encoding a Renilla luciferase (Rluc) reporter, and six single-residue substitution mutants were generated: L128F and S158P in the non-structural protein (NS) 3 protease domain gene, and N96I, N390A, K437R and M805I in the NS5 gene.

Identification of Specific Nucleotide Sequences within the Conserved 3′-SL in the Dengue Type 2 Virus Genome Required for Replication

This work examined the requirement for the 3′-SL in the context of dengue virus type 2 (DEN2) replication by mutagenesis of an infectious cDNA copy of a DEN2 genome and suggested that the wt DEN2 nucleotide sequence forming the bottom half of the long stem and loop in the 3″-SL was required for viability.

Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay

ABSTRACT Dengue virus (DENV) causes disease globally, with an estimated 25 to 100 million new infections per year. At present, no effective vaccine is available, and treatment is supportive. In this

Infectious RNA transcripts from full-length dengue virus type 2 cDNA clones made in yeast

Intracellular dengue virus RNA from cells infected with transcript-derived virus contained an introduced BstEII site, proving that infectivity was derived from RNA transcripts and not from contamination with parental d Dengue virus.

Dengue 3 virus transmission in Africa.

The first known transmission of dengue 3 virus in Africa was documented by virus isolation during an epidemic of dengue-like illness in Pemba, Mozambique, in late 1984 and early 1985. Dengue 3 virus