The Delta intracellular domain mediates TGF-β/Activin signaling through binding to Smads and has an important bi-directional function in the Notch–Delta signaling pathway

@inproceedings{Hiratochi2007TheDI,
  title={The Delta intracellular domain mediates TGF-β/Activin signaling through binding to Smads and has an important bi-directional function in the Notch–Delta signaling pathway},
  author={Masahiro Hiratochi and Hisashi Nagase and Yu Kuramochi and Chang-sung Koh and Takeshi Ohkawara and Kohzo Nakayama},
  booktitle={Nucleic acids research},
  year={2007}
}
Delta is a major transmembrane ligand for Notch receptor that mediates numerous cell fate decisions. The Notch signaling pathway has long been thought to be mono-directional, because ligands for Notch were generally believed to be unable to transmit signals into the cells expressing them. However, we showed here that Notch also supplies signals to neighboring mouse neural stem cells (NSCs). To investigate the Notch-Delta signaling pathway in a bi-directional manner, we analyzed functional roles… CONTINUE READING
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