The Delay in Recovery from Fast Inactivation in Skeletal Muscle Sodium Channels Is Deactivation

Abstract

1. Using macropatch techniques, we tested the assumption that deactivation underlies the observed delay in the onset to recovery from fast inactivation by comparing open-state deactivation to recovery delay for rat skeletal muscle mutations R1441C and R1441P. 2. Deactivation kinetics from the open state were determined from the exponential decay of tail… (More)
DOI: 10.1023/A:1007040731407

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