The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics

Abstract

To study the potential impact of the degradation of Polysorbates (PS) 20 and 80 on the stability of therapeutic proteins in parenteral formulations. First, degradation products of PS20 and 80 were identified. Subsequently, the effect of degraded polysorbate on physical characteristics and long-term stability of protein formulations was assessed. Further… (More)
DOI: 10.1007/s11095-011-0385-x

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@article{Kishore2011TheDO, title={The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics}, author={Ravuri S. K. Kishore and Sylvia Kiese and Stefan Fischer and Astrid Pappenberger and Ulla Grauschopf and H Mahler}, journal={Pharmaceutical Research}, year={2011}, volume={28}, pages={1194-1210} }