The Defect in Fas mRNA Expression in MRL / Ipr Mice Is Associated with Insertion of the Retrotransposon , ETn

@inproceedings{Chu2003TheDI,
  title={The Defect in Fas mRNA Expression in MRL / Ipr Mice Is Associated with Insertion of the Retrotransposon , ETn},
  author={J Chu and Jorn Drappa and Andrew P Parnassa and Keith B Elkon},
  year={2003}
}
Fas is a cell surface protein of the tumor necrosis factor receptor, nerve growth factor receptor, CD40 family, and is involved in the control of lymphocyte apoptosis. A mutation in the Fas gene in MRL/Ipr mice results in massive lymphoproliferation (Ipr) and accelerated autoimmunity. To further study the nature of this defect, Fas mRNA expression was… CONTINUE READING