The Deep Origin and Recent Loss of Venom Toxin Genes in Rattlesnakes

  title={The Deep Origin and Recent Loss of Venom Toxin Genes in Rattlesnakes},
  author={Noah L. Dowell and Matt W. Giorgianni and Victoria A. Kassner and Jane E. Selegue and Elda Eliza S{\'a}nchez and Sean B. Carroll},
  journal={Current Biology},
The genetic origin of novel traits is a central but challenging puzzle in evolutionary biology. Among snakes, phospholipase A2 (PLA2)-related toxins have evolved in different lineages to function as potent neurotoxins, myotoxins, or hemotoxins. Here, we traced the genomic origin and evolution of PLA2 toxins by examining PLA2 gene number, organization, and expression in both neurotoxic and non-neurotoxic rattlesnakes. We found that even though most North American rattlesnakes do not produce… CONTINUE READING
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Structures and functions of crotoxin-like heterodimers and acidic phospholipases A2 fromGloydius intermedius venom: insights into the origin of neurotoxic-type rattlesnakes

  • Yang, Z.-M, +9 authors I.-H
  • J. Proteomics
  • 2015
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