The Decapentaplegic morphogen gradient: from pattern formation to growth regulation

  title={The Decapentaplegic morphogen gradient: from pattern formation to growth regulation},
  author={Markus Affolter and Konrad Basler},
  journal={Nature Reviews Genetics},
Morphogens have been linked to numerous developmental processes, including organ patterning and the control of organ size. Here we review how different experimental approaches have led to an unprecedented level of molecular knowledge about the patterning role of the Drosophila melanogaster morphogen Decapentaplegic (DPP, the homologue of vertebrate bone morphogenetic protein, or BMP), the first validated secreted morphogen. In addition, we discuss how little is known about the role of the DPP… CONTINUE READING
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