The Debate on Carcinogenicity of Permanent Hair Dyes: New Insights

@article{Bolt2007TheDO,
  title={The Debate on Carcinogenicity of Permanent Hair Dyes: New Insights},
  author={Hermann M. Bolt and Klaus Golka},
  journal={Critical Reviews in Toxicology},
  year={2007},
  volume={37},
  pages={521 - 536}
}
  • H. Bolt, K. Golka
  • Published 1 January 2007
  • Chemistry
  • Critical Reviews in Toxicology
Oxidative (permanent) hair dyes contain one or several “primary intermediates” (e.g., p-phenylenediamines, p-aminophenols) and “couplers” (e.g., m-aminophenols, m-hydroxyphenols). In the presence of peroxide, the primary intermediate(s) and the coupler(s) undergo a chemical reaction to form colored oligomers. In the 1970s a number of aromatic amines used in oxidative hair dyes were identified as mutagenic and/or carcinogenic in rodents after lifetime oral administration. In response, regulatory… 
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TLDR
The Expert Panel expects that following this procedure will prospectively identify individuals who would have an irritation/sensitization reaction and allow them to avoid significant exposures and concluded that 3-Methylamino-4-Nitrophenoxyethanol is safe as a cosmetic ingredient in the practices of use and use concentrations described in this safety report.
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